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Variations in serum müllerian inhibiting substance between white, black, and Hispanic women
David B Seifer1, Elizabeth T Golub, Geralyn Lambert-Messerlian
1Department of Obstetrics and Gynecology, Brooklyn, and Mount Sinai School of Medicine, Maimonides Medical Center, New York, New York 11228, USA. drseifer@genesisfertility.com
Objective:
To compare serum müllerian inhibiting substance (MIS) levels between white, black, and Hispanic women to determine whether ovarian aging occurs at a different time course for women of different racial groups.
Design:
Longitudinal study of serum MIS levels in women of different race and ethnicity over two different time points.
Setting:
Women's Interagency HIV Study, a multicenter prospective cohort study.
Patient(S):
Serum samples obtained from 809 participants (122 white, 462 black, and 225 Hispanic women).
Intervention(S):
Comparison of serum MIS between women of different race and ethnicity at two time points (median age 37.5 years and 43.3 years).
Main Outcome Measure(S):
Variation in MIS by race and ethnicity over time, controlling for age, body mass index, HIV status, and smoking.
Result(S):
Compared with white women, average MIS values were lower among black (25.2% lower) and Hispanic (24.6% lower) women, adjusting for age, body mass index, smoking, and HIV status.
Conclusion(S):
There is an independent effect of race and ethnicity on the age-related decline in MIS over time.
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