Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alemtuzumab in combination with methylprednisolone is a highly effective induction regimen for patients with chronic lymphocytic leukemia and deletion of TP53: final results of the national cancer research institute CLL206 trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2012
Same author

Searching for surrogates for IGHV mutations in chronic lymphocytic leukemia.

Leukemia research·2011
Same author

The Myelodysplastic Syndromes (MDS) Foundation: a retrospective analysis of a nonprofit foundation.

Leukemia research·2010
Same author

The TCL1 mouse as a model for chronic lymphocytic leukemia.

Leukemia research·2009
Same author

Just exactly how common is CLL?

Leukemia research·2009
Same author

Fludarabine, cyclophosphamide and rituximab for chronic lymphocytic leukemia: no country for old men?

Nature clinical practice. Oncology·2009
Same journal

A multicenter real-world study of clinical outcomes in octogenarians and older patients with acute myeloid leukemia.

Leukemia research·2026
Same journal

FLAMSA versus FLAG-IDA as salvage therapy in adults with relapsed/refractory acute myeloid leukemia and acute lymphoblastic leukemia: A single-center real-world retrospective study.

Leukemia research·2026
Same journal

CD244 modulates bone marrow infiltrating CD8<sup>+</sup> T cells and serves as a prognostic and immunotherapeutic target in acute myeloid leukemia.

Leukemia research·2026
Same journal

Long-term remission and survival in older adults with IDH-mutated acute myeloid leukemia treated with IDH inhibitors.

Leukemia research·2026
Same journal

Real-world outcomes of plasmablastic lymphoma: Treatment approaches and survival outcomes in the PLASMABLAT-001 cohort.

Leukemia research·2026
Same journal

CRS and ICANS as class-level adverse event for CD20 ×CD3 bispecific T-cell engagers: A Bayesian analysis of a nationwide database.

Leukemia research·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

Non-hemic autoimmunity in CLL.

Terry J Hamblin

    Leukemia Research
    |October 22, 2008
    PubMed
    Summary
    This summary is machine-generated.

    Non-hemic autoimmune complications are rare in chronic lymphocytic leukemia (CLL), unlike common blood-related autoimmune issues. Only acquired angioedema, glomerulonephritis, and paraneoplastic pemphigus are clearly linked to CLL.

    More Related Videos

    The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
    09:03

    The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

    Published on: February 3, 2012

    A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
    09:52

    A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia

    Published on: December 4, 2018

    Related Experiment Videos

    Last Updated: Jun 28, 2026

    Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
    09:02

    Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

    Published on: November 26, 2018

    The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
    09:03

    The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

    Published on: February 3, 2012

    A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
    09:52

    A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia

    Published on: December 4, 2018

    Area of Science:

    • Hematology
    • Immunology
    • Oncology

    Background:

    • Non-hemic autoimmune complications are infrequent in chronic lymphocytic leukemia (CLL), contrasting with the higher prevalence of autoimmune hemolytic anemia (10-20%) and immune thrombocytopenia (1-2%).
    • Established non-hemic syndromes associated with CLL include acquired angioedema, glomerulonephritis, and paraneoplastic pemphigus.

    Discussion:

    • Acquired angioedema in CLL is linked to a tumor-secreted product.
    • Glomerulonephritis and paraneoplastic pemphigus appear to stem from immune dysregulation, potentially influenced by purine analogue treatments and regulatory T cells.
    • Neurological syndromes in CLL are uncommon, typically attributed to leukemic CNS infiltration or progressive multifocal leukoencephalopathy, with Herpes Zoster infections being an exception.

    Key Insights:

    • CLL patients face rare non-hemic autoimmune risks beyond common hematologic complications.
    • Specific non-hemic syndromes like acquired angioedema, glomerulonephritis, and paraneoplastic pemphigus have a defined relationship with CLL.
    • Immune system dysregulation, possibly involving T cells and purine analogue therapy, may underlie some non-hemic complications.

    Outlook:

    • Further research into the mechanisms of non-hemic autoimmune complications in CLL is warranted.
    • Understanding these rare associations may lead to improved diagnostic and therapeutic strategies for CLL patients.
    • Investigating the role of regulatory T cells and treatment effects could refine management of CLL-associated autoimmune conditions.