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Updated: Jun 28, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
[Physico-chemical stability and sterility of non-opioid analgesics in solution]
A Troïtzky1, M Tirault, S Lefeuvre
1Département d'anesthésie-réanimation, hôpital Jean-Bernard, 2, rue de la Milétrie, BP 577, 86021 Poitiers cedex, France. annetroitzky@aol.com
Objectives:
The combination of non-opioid analgesic drugs (P: paracetamol, K: ketoprofen and N: nefopam) is currently recommended for postoperative pain control. In practice, these analgesics are often administered in the same solution. We investigated the chemical stability and sterility of three mixtures of analgesics (P+K, P+N and K+N).
Methods:
For each mixture, concentrations of active principles were measured using high-performance liquid chromatography over 24 hours. These mixtures were cultured for microbiological colonization.
Results:
Our study demonstrated chemical and bacteriologic stability of these three mixtures over a 24-hour period. The results allow the use of P+K, P+N and K+N in the same ready to use solution.
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