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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Related Experiment Video

Updated: Jun 28, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

[Transfusion in elderly patients].

M Godard1, A Forest, M Verny

  • 1Centre de gériatrie, hôpital Pitié-Salpêtrière, AP-HP, UPMC, Paris, France.

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|October 22, 2008
PubMed
Summary
This summary is machine-generated.

Anemia frequently leads to blood transfusions in elderly patients. Careful management is crucial due to atypical symptoms, comorbidities, and sensitivity to overload, necessitating further research.

Related Experiment Videos

Last Updated: Jun 28, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

  • Geriatrics
  • Hematology
  • Internal Medicine

Background:

  • Anemia is common in elderly patients, often necessitating blood transfusions.
  • Transfusions in this population present unique challenges due to atypical presentations and comorbidities.
  • Elderly individuals are more susceptible to transfusion-related adverse events like fluid overload.

Purpose of the Study:

  • To highlight the complexities and risks associated with blood transfusions in the elderly population.
  • To underscore the limitations of current guidelines in managing elderly patients requiring transfusion.
  • To emphasize the need for evidence-based practices through prospective studies.

Main Methods:

  • This study is a review of current challenges and considerations for blood transfusion in elderly patients.
  • It synthesizes existing knowledge on geriatric anemia and transfusion medicine.
  • No new clinical data was generated; it's an analysis of existing practices and literature.

Main Results:

  • Elderly patients exhibit atypical signs of anemia, making tolerance difficult to assess.
  • Heterogeneous comorbidities in the elderly limit the applicability of standard transfusion guidelines.
  • The elderly are prone to iatrogenic complications, requiring careful hemodynamic monitoring during transfusions.

Conclusions:

  • Transfusion management in elderly patients requires heightened vigilance due to specific physiological and clinical factors.
  • Current guidelines may not adequately address the complexities of transfusing older adults.
  • Prospective studies are essential to develop and validate best practices for blood transfusion in the elderly.