Related Experiment Videos
IGF1 as predictor of all cause mortality and cardiovascular disease in an elderly population
Mikkel Andreassen1, Ilan Raymond, Caroline Kistorp
1Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark. andreassenmikkel@hotmail.com
Insights
High insulin-like growth factor 1 (IGF1) levels are linked to increased mortality and chronic heart failure (CHF) risk in older adults. This study found no association between IGF1 and major cardiovascular events.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Gerontology
Background:
- Insulin-like growth factor 1 (IGF1) plays a complex role in aging and cardiovascular disease (CVD).
- Reduced IGF1 signaling is linked to increased lifespan in animal models and potentially human longevity.
- The relationship between IGF1 levels and age-related diseases, including CVD, requires further investigation.
Purpose of the Study:
- To investigate the association between plasma IGF1 levels and all-cause mortality.
- To examine the relationship between IGF1 levels and the development of chronic heart failure (CHF).
- To assess the association of IGF1 levels with major adverse cardiovascular events (MACE).
Main Methods:
- A population-based study involving 642 individuals aged 50-89 years.
- Assessment of CHF development in 576 individuals with preserved systolic function and no prior CHF or myocardial infarction.
- Evaluation of first major CV event in 504 individuals with preserved systolic function and no prevalent CVD, with 5-year follow-up.
Main Results:
- Higher IGF1 levels (fourth quartile) were independently associated with increased all-cause mortality (HR 1.52, P=0.044).
- Elevated IGF1 levels were significantly associated with a higher risk of developing CHF (HR 5.02, P=0.001).
- No significant association was found between IGF1 levels and the overall incidence of major CV events (HR 1.05, P=0.861).
Conclusions:
- High plasma IGF1 levels are independently associated with increased all-cause mortality in older adults.
- Elevated IGF1 levels are a risk factor for the development of chronic heart failure.
- The study did not find a relationship between IGF1 levels and the overall incidence of major cardiovascular events.
Background:
IGF1 is believed to influence ageing and development of cardiovascular disease (CVD) through complex mechanisms. Reduced IGF1 levels might be causally associated with conditions accompanying ageing including development of CVD. However, in animal models reduced GH-IGF1 signalling increases lifespan. Reduced IGF1 activity might also be associated with longevity in humans.
Objective:
The objective was to investigate if plasma IGF1 levels were associated with all cause mortality, and the development of chronic heart failure (CHF) and a major CV event.
Patients And Design:
A population based study of 642 individuals, aged 50-89 years. Development of CHF was evaluated in 576 individuals with normal systolic function assessed by echocardiography and without the history of CHF or myocardial infarction. Development of the first major CV event was evaluated in 504 individuals with normal systolic function and without prevalent CVD. Outcomes were ascertained after 5 years using hospital discharge diagnoses.
Results:
Adjustment for risk factors IGF1 values in the fourth quartile versus values below the fourth quartile was associated with increased mortality (n=103), hazard ratio (HR) 1.52 (95% confidence interval (CI) 1.01-2.28; P=0.044). IGF1 in the fourth quartile was also independently associated with risk of development of CHF (n=19), HR 5.02 (95% CI 2.00-12.64; P=0.001) but showed no association with the overall incidence of major CV events (n=58), HR 1.05 (95% CI 0.59-1.90; P=0.861).
Conclusions:
High IGF1 levels were independently associated with increased all cause mortality and risk of development of CHF, whereas no relation with the overall incidence of CVD was observed.
