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Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
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Published on: January 20, 2022

The SWISS-MODEL Repository and associated resources.

Florian Kiefer1, Konstantin Arnold, Michael Künzli

  • 1Biozentrum, University of Basel and SIB Swiss Institute of Bioinformatics, Basel, Switzerland.

Nucleic Acids Research
|October 22, 2008
PubMed
Summary

The SWISS-MODEL Repository offers millions of 3D protein structure models for researchers. This updated database provides access to annotated protein models and tools for quality assessment and interactive model building.

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Area of Science:

  • Structural Biology
  • Bioinformatics
  • Computational Biology

Background:

  • Homology modeling is crucial for predicting protein structures.
  • Databases of protein models enhance structural biology research.
  • Automated pipelines streamline the generation of protein models.

Purpose of the Study:

  • To provide an updated, comprehensive database of 3D protein structure models.
  • To offer access to annotated models generated by automated homology modeling.
  • To facilitate navigation between protein sequence and structure resources.

Main Methods:

  • Utilizing the SWISS-MODEL homology-modeling pipeline.
  • Automated generation of 3D protein models for Swiss-Prot and model organisms.
  • Regular updates incorporating the latest sequence and structure databases.

Main Results:

  • The SWISS-MODEL Repository contains 3.4 million entries for 2.7 million protein sequences (as of Sept 2008).
  • Provides tools for model quality assessment and interactive model building via SWISS-MODEL Workspace.
  • Includes functional annotations and cross-links to other databases like the Protein Model Portal.

Conclusions:

  • The SWISS-MODEL Repository is a valuable, up-to-date resource for 3D protein models.
  • Automated modeling and regular updates ensure comprehensive and high-quality structural data.
  • Enhanced accessibility and integration with other resources support protein research.