Related Experiment Video
Updated: Jun 28, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
Controlling the activity of peptides and proteins with smart nucleic acid-protein hybrids
1Department of Chemistry, Humboldt-Universität zu Berlin, Berlin, Germany.
Abstract:
Oligonucleotide-peptide conjugates have frequently been used to control the localisation of the conjugate molecule. For example, the oligonucleotide segment has allowed spatially addressed immobilization of peptides and proteins on DNA-arrays via hybridisation while the peptide part has most frequently been used to confer transfer of oligonucleotide cargo into live cells. The regulation of functional properties such as the affinity of these bioconjugates for protein targets has rarely been addressed. This review article describes the current developments in the application of smart oligonucleotide-peptide hybrids. The mutual recognition between nucleic acid segments is used to constrain the structure or control the distance between peptide and protein segments. Application of these new type of oligonucleotide-peptide hybrids allowed not only the regulation of binding affinity of peptide ligands but also control of enzymatic and optical activity of proteins.
More Related Videos
Related Concept Videos
Tagging and Fusion Proteins
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein.
Nucleic Acid Structure
DNA Structure
DNA has a double-helix structure. The...
Regulation of Nuclear Protein Sorting
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Experimental RNAi

