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Published on: February 17, 2023
Nifedipine regulated periodontal ligament remodeling: an experimental study in rats
Miao-Miao Zhang1, Dong-Fei Feng, Ping Shao
1Department of Orthodontics, College of Stomatology, Harbin Medical University, Harbin 150001, PR China.
Objective:
The aim of this study was to investigate the effects of nifedipine on periodontal ligament remodeling during orthodontic tooth movement.
Material And Methods:
Sixty male Sprague-Dawley rats were randomly divided into an orthodontic group and groups that received either 10 mg/kg or 40 mg/kg nifedipine (NIF). Immunohistochemical staining and image analysis were used to investigate the expression of matrix metalloproteinase (MMP)-1, -10, -13 and collagen-I in PDL, and maxillary 1st molar displacement was measured.
Results:
Expression of MMP-1, -10, and -13 was significantly decreased in both NIF groups, while collagen-I expression was markedly increased. NIF significantly inhibited tooth movement.
Conclusions:
NIF affects the expression of MMP-1, -10, -13 and collagen-I and tooth movement induced by orthodontic force in rats, thus indicating that calcium channels might be important in mediating PDL remodeling.
