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Published on: August 16, 2018
Two new bioactive oleanane triterpene glycosides from Terminalia arjuna
M Sarwar Alam1, Gurpreet Kaur, Asif Ali
1Faculty of Science, Department of Chemistry, Jamia Hamdard, New Delhi 110062, India. msalamchem@yahoo.com
Natural Product Research
|October 22, 2008
Summary
Two novel oleanane-type triterpene glycosides, Termiarjunoside I and II, were isolated from Terminalia arjuna bark. These compounds effectively reduced nitric oxide and superoxide release from macrophages and inhibited platelet aggregation.
Area of Science:
- Phytochemistry
- Pharmacology
- Natural Products Chemistry
Background:
- Terminalia arjuna (Combretaceae) is a medicinal plant with a history of traditional use.
- Triterpene glycosides are a class of natural compounds known for diverse biological activities.
Purpose of the Study:
- To isolate and characterize new triterpene glycosides from Terminalia arjuna stem bark.
- To evaluate the in vitro biological activities of the isolated compounds.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation through comprehensive spectroscopic analyses (NMR, MS).
- Assessment of nitric oxide and superoxide release from macrophages.
- Evaluation of platelet aggregation inhibition.
Main Results:
- Two new oleanane-type triterpene glycosides, Termiarjunoside I and Termiarjunoside II, were identified and characterized.
- Both compounds demonstrated potent suppression of nitric oxide and superoxide release from macrophages.
- Compounds 1 and 2 exhibited significant inhibition of platelet aggregation.
Conclusions:
- Termiarjunoside I and II represent novel bioactive compounds from Terminalia arjuna.
- These findings suggest potential therapeutic applications for these triterpene glycosides in inflammatory and thrombotic conditions.
