[Determination of mefenoxalone in substances, tablets and biological materials]

For the determination of mefenoxalon in substance, tablets and biological material (blood plasma), four variants were worked out. The first of them is based on the substitution of the benzene ring with bromine with the use of an excess of bromine, which is determined ionometrically. The second variant is based on direct titration of the hydrolytic product mefenoxalon, 3-(2-methoxyphenoxy)-2-hydroxypropylamine, with the use of the ion-selective electrode of the coated-wire type with a volumetric solution of tetraphenyl-borsodium. The third variant utilizes direct measurements of UV spectra of mefenoxalon in a solution of dichlorethane. The fourth variant consists in its fluorimetric measurement in a solution of dichlorethane, or ethylacetate. A detailed discussion of advantages and disadvantages of all above-mentioned variants of determination is presented.