Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Propranolol and morphine.

G Navarro, R Richardson, A T Zuban

    Psychopharmacology
    |December 21, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Propranolol does not block morphine effects in mice. However, this beta-blocker exhibits anticonvulsant properties, particularly against the tonic phase of seizures, indicating central nervous system activity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evidence for the Collective Nature of Radial Flow in Pb+Pb Collisions with the ATLAS Detector.

    Physical review letters·2026
    Same author

    Evidence for the Dimuon Decay of the Higgs Boson in pp Collisions with the ATLAS Detector.

    Physical review letters·2025
    Same author

    Integrated meteocean and seismic dataset for AI-based seawater CO<sub>2</sub> estimation at Deception Island, Antarctica.

    Scientific data·2025
    Same author

    Evidence for Longitudinally Polarized W Bosons in the Electroweak Production of Same-Sign W Boson Pairs in Association with Two Jets in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

    Physical review letters·2025
    Same author

    The role of Sb-over-Te ratio on the structural evolution of GeSbTe phase-change materials.

    Scientific reports·2025
    Same author

    Observation of tt[over ¯] Production in Pb+Pb Collisions at sqrt[s_{NN}]=5.02  TeV with the ATLAS Detector.

    Physical review letters·2025
    Same journal

    Sotagliflozin pretreatment attenuates acute LPS-induced depression-like behavioral abnormalities and modulates the gut microbiota-immune-brain axis.

    Psychopharmacology·2026
    Same journal

    GlyT1 inhibition enhances working memory in the mouse TUNL task and normalizes NMDA antagonist-induced network activity.

    Psychopharmacology·2026
    Same journal

    Effects of repeated treatment with opioids that vary in mu opioid receptor efficacy on pain-depressed locomotor behavior in mice.

    Psychopharmacology·2026
    Same journal

    Cannabidiol in the anterior insular cortex attenuates chronic neuropathic pain and comorbid anxiety- and depression-like behaviors: involvement of CB<sub>1</sub> and 5-HT<sub>1A</sub> receptor signaling.

    Psychopharmacology·2026
    Same journal

    Fentanyl decreases arterial blood oxygen saturation more than furanylfentanyl in mice due to increased apnea.

    Psychopharmacology·2026
    Same journal

    Suicide attempt risk among patients receiving methylphenidate: a retrospective cohort study.

    Psychopharmacology·2026
    See all related articles

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Central Nervous System (CNS) Research

    Background:

    • Propranolol, a beta-adrenergic receptor antagonist, is known to cross the blood-brain barrier.
    • Its potential interactions with opioid systems and direct CNS effects warrant investigation.

    Purpose of the Study:

    • To evaluate the morphine-blocking and anticonvulsant effects of propranolol in a murine model.
    • To differentiate propranolol's effects from those mediated by beta-blockade using sotalol as a control.

    Main Methods:

    • Administered propranolol and sotalol to mice subjected to electroshock, pentylenetetrazol, and thebaine-induced seizures.
    • Determined the median lethal dose (LD50) of morphine following propranolol pretreatment.

    Main Results:

    Related Experiment Videos

    • Propranolol did not alter the median lethal dose (LD50) of morphine in mice.
    • Propranolol demonstrated anticonvulsant effects, primarily on the tonic phase of seizures, distinct from sotalol's activity.
    • Sotalol, a less CNS-penetrant beta-blocker, showed different anticonvulsant characteristics.

    Conclusions:

    • The study does not support propranolol as a morphine antagonist.
    • Propranolol possesses significant central nervous system effects independent of its beta-blocking activity.
    • Propranolol's anticonvulsant action is specific and suggests direct CNS mechanisms.