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Related Experiment Videos

Hydrogel keratophakia: long-term morphology in the monkey model.

R A Parks1, B E McCarey

  • 1Emory University School of Medicine, Department of Ophthalmology, Atlanta, GA 30322.

The CLAO Journal : Official Publication of the Contact Lens Association of Ophthalmologists, Inc
|July 1, 1991
PubMed
Summary

Hydrogel intracorneal lenses showed long-term biocompatibility in a rhesus monkey after 8.5 years. Minimal pathological changes were observed, indicating the synthetic plastic

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Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Corneal Research

Background:

  • Intracorneal implants are used in ophthalmology.
  • Long-term effects of synthetic plastics in the cornea require investigation.

Purpose of the Study:

  • To evaluate the long-term effects of hydrogel (Permalens) intracorneal implants in a primate model.
  • To assess the biocompatibility of synthetic plastics within the primate cornea over 8.5 years.

Main Methods:

  • Light microscopy and transmission electron microscopy were used for evaluation.
  • A rhesus monkey with bilateral hydrogel intracorneal implants was studied.
  • Corneal tissue was analyzed after 8.5 years of implantation.

Main Results:

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  • Hydrogel lenticules were implanted at 80-90% stromal depth, causing posterior stromal bulging.
  • Minor pathological changes included epithelial remodeling and vacuolated endothelial cells.
  • No inflammatory reaction was observed in the cornea histologically.

Conclusions:

  • Hydrogel intracorneal lenses demonstrate long-term biocompatibility in primates.
  • Synthetic plastics can be safely integrated into the cornea long-term.
  • This study supports the use of hydrogel intracorneal implants.