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Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

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Bioavailability is a crucial pharmacokinetic parameter that quantifies the proportion of an administered drug that reaches the systemic circulation and is available for therapeutic action. Regulatory agencies mandate the assessment of bioavailability, typically measured as the area under the drug plasma concentration-versus-time curve (AUC), to ensure the efficacy and safety of pharmaceutical products. These evaluations are categorized as absolute and relative bioavailability studies.Absolute...
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Related Experiment Video

Updated: Jun 28, 2026

Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells
05:56

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Published on: November 12, 2020

Variability in absolute apparent diffusion coefficient values across different platforms may be substantial: a

Makoto Sasaki1, Kei Yamada, Yoshiyuki Watanabe

  • 1Advanced Medical Research Center, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, Japan. masasaki@iwate-med.ac.jp

Radiology
|October 22, 2008
PubMed
Summary
This summary is machine-generated.

Absolute apparent diffusion coefficient (ADC) values show significant variability across different MRI scanners, vendors, and field strengths. Relative ADC values may be more reliable for multicenter stroke trials.

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Area of Science:

  • Radiology
  • Medical Imaging
  • Neuroimaging

Background:

  • Apparent diffusion coefficient (ADC) values are crucial for quantitative MRI analysis.
  • Variability in ADC measurements can impact diagnostic accuracy in multicenter studies.

Purpose of the Study:

  • To quantify the variability of absolute ADC values across different MRI systems.
  • To assess the influence of imagers, vendors, field strengths, and intra-imager conditions on ADC measurements.

Main Methods:

  • Diffusion-weighted MRI scans were acquired from 12 healthy volunteers at 1.5T and 3.0T across seven institutions.
  • Ten MRI scanners from four vendors were used with standardized imaging parameters.
  • ADC maps were generated, and mean pixel values for brain tissues were calculated.

Main Results:

  • Substantial variations in absolute ADC values were observed (4%-9%) for gray and white matter from the same vendor.
  • Inter-vendor variability reached up to 7% at 1.5T.
  • Intra-imager variability, influenced by coil systems, was as high as 8%.

Conclusions:

  • Absolute ADC values exhibit significant variability due to differences in MRI hardware and acquisition parameters.
  • Relative ADC values are recommended over absolute ADC for evaluating diffusion abnormalities in multicenter acute ischemic stroke trials.