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Related Concept Videos

Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Giardiasis01:12

Giardiasis

Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...
Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
American Trypanosomiasis01:22

American Trypanosomiasis

Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...

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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Published on: August 22, 2012

Cutaneous amebiasis in pediatrics.

Mario L Magaña1, Jorge Fernández-Díez, Mario Magaña

  • 1Hospital General de México and School of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico. dermatopatología@hotmail.com

Archives of Dermatology
|October 22, 2008
PubMed
Summary

Cutaneous amebiasis (CA) presents as painful ulcers, easily diagnosed microscopically. Erythrophagocytosis is a key sign, with amebae reaching skin through direct or indirect routes.

Area of Science:

  • Medical Mycology
  • Parasitology
  • Dermatology

Background:

  • Cutaneous amebiasis (CA) remains a significant health concern in developing nations.
  • Accurate diagnosis relies on clinical and histopathologic examination.

Purpose of the Study:

  • To review clinical and histopathologic features of cutaneous amebiasis.
  • To understand diagnostic methods and amebic mechanisms in skin infections.

Main Methods:

  • Retrospective review of 26 cutaneous amebiasis cases (1955-2005).
  • Analysis of patient demographics, clinical presentation, comorbidities, diagnostic methods, and microscopic findings.

Main Results:

  • Cutaneous amebiasis consistently presents with painful ulcers.

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  • Microscopic examination of ulcers reveals amebae, with erythrophagocytosis being a definitive diagnostic indicator.
  • Amebae access the skin via direct or indirect pathways, requiring a skin lesion and favorable host conditions.
  • Conclusions:

    • Cutaneous amebiasis diagnosis is aided by identifying amebae and erythrophagocytosis in painful ulcers.
    • Understanding amebic invasion mechanisms is crucial for managing skin infections.
    • Early diagnosis and treatment are vital for patients with cutaneous amebiasis.