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Published on: May 26, 2022
Treatment considerations for the hypertensive patient over age 55
1Whitaker Cardiovascular Institute, Boston University School of Medicine, Massachusetts 02164.
Insights
Hypertension treatment in older adults (over 55) can reduce complications, though systolic hypertension treatment is less understood. Special considerations are needed due to physiological changes and potential drug interactions in the elderly.
Area of Science:
- Gerontology
- Cardiovascular Medicine
- Pharmacology
Background:
- Hypertension prevalence significantly increases with age, with most affected individuals over 55.
- Older hypertensive patients face risks for major cardiovascular and renal complications, potentially higher for sudden death and dementia.
Purpose of the Study:
- To review the challenges and considerations in managing hypertension in patients over age 55.
- To highlight the benefits of pharmacotherapy in reducing diastolic hypertension complications in the elderly.
Main Methods:
- Literature review focusing on age-related physiological changes affecting hypertension management.
- Analysis of pharmacotherapy outcomes for diastolic hypertension in older populations.
- Consideration of factors impacting therapeutic compliance in the elderly.
Main Results:
- Pharmacotherapy effectively reduces diastolic hypertension complications in individuals over 55.
- Older adults exhibit unique physiological alterations (e.g., reduced renal function, altered baroreceptor reflexes) impacting treatment.
- Pseudohypertension due to arteriosclerosis is a consideration in elderly patients.
Conclusions:
- Managing hypertension in older adults requires tailored approaches due to physiological changes, comorbidities, and compliance issues.
- While systolic hypertension treatment needs further understanding, diastolic hypertension pharmacotherapy offers significant benefits for this population.
Abstract:
The prevalence of hypertension increases with age. The majority of the hypertensive population is over age 55. Although the treatment of systolic hypertension remains incompletely understood, the reduction of diastolic hypertension with pharmacotherapy has been shown to reduce complications from hypertension in persons over age 55. The older hypertensive patient is at risk for the same complications as the younger patient: angina, myocardial infarction, arteriosclerosis obliterans, stroke, myocardial hypertrophy, congestive heart failure, and renal failure; the risk of sudden death and multi-infarct dementia in the older patient may be somewhat higher. The older hypertensive individual may have reduced plasma volume and defective salt and water conservation, reduced renal function, impairment of baroreceptor reflexes and sympathetic reactivity, and altered drug pharmacokinetics, or may have arteriosclerosis leading to pseudohypertension. Many circumstances interfere with adequate compliance with therapeutic regimens among the elderly. Concomitant medical conditions increase the possibility of drug interactions and require that the practitioner be able to adjust the antihypertensive program to the patient.
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