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Related Concept Videos

Stability of structures01:14

Stability of structures

In mechanical engineering, the stability of systems under various forces is critical for designing durable and efficient structures. One fundamental way to explore these concepts is by analyzing systems like two rods connected at a pivot point, O, with a torsional spring of spring constant k at the pivot point. This system is similar in appearance to a scissor jack used to change tires on a car. In this case, the arms of the linkage (equivalent to the rods in this system) are entirely vertical,...
Disassembly of Intermediate Filaments01:35

Disassembly of Intermediate Filaments

Intermediate filaments (IFs) do not undergo spontaneous disassembly. Enzymes, kinases, and phosphatases add and remove phosphates from specific sites to regulate their disassembly. The IF concentration in the cytoplasm also regulates the disassembly. If the concentration crosses a threshold, it activates the protein kinases in the vicinity, allowing the phosphorylation of IFs.
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Relationship Formation02:12

Relationship Formation

What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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Destabilization of Microtubules01:45

Destabilization of Microtubules

The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at either end of the microtubule or in the microtubule lattices as a whole. The lifespan of individual microtubules within a cell varies according to the cell type and stage of the cell cycle. During interphase, the lifespan of the microtubule is about 30 minutes, while during cell division, it is about 15 minutes. In axonal microtubules of...
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Restarting Stalled Replication Forks

DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart, a...

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Related Experiment Video

Updated: Jun 28, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
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Published on: December 7, 2021

Asymmetric disassembly and robustness in declining networks.

Serguei Saavedra1, Felix Reed-Tsochas, Brian Uzzi

  • 1Department of Engineering Science and CABDyN Complexity Centre, Oxford University, Oxford OX1 3PJ, United Kingdom.

Proceedings of the National Academy of Sciences of the United States of America
|October 22, 2008
PubMed
Summary

Declining networks can maintain structure and function by favoring asymmetric links during contraction. This strategy helps preserve network integrity even with significant node loss, unlike simple reverse growth processes.

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Area of Science:

  • Network Science
  • Sociology
  • Economics

Background:

  • Understanding how networks maintain structure during decline is crucial but poorly understood.
  • Existing models predominantly focus on network growth, neglecting decline dynamics.
  • Data on declining networks is scarce, limiting research in this area.

Purpose of the Study:

  • To investigate the mechanisms that allow declining networks to avoid structural collapse and performance degradation.
  • To analyze the evolution of network topology and global performance during decline.
  • To develop and test a model explaining network robustness under contraction.

Main Methods:

  • Analysis of over 700,000 firm transactions in the New York garment industry over 19 years.
  • Tracking network decline, topology, and global performance evolution.
  • Developing and simulating a network decline model combining asymmetric disassembly and preferential attachment.

Main Results:

  • Favoring asymmetric (disassortative) links is critical for preserving the topology and functionality of declining networks.
  • The proposed model successfully explains network robustness during decline, even with over an order of magnitude contraction in nodes.
  • Disassembly processes in network decline are distinct from simple reverse assembly mechanisms.

Conclusions:

  • Asymmetric link formation is a key strategy for network resilience during decline.
  • The developed model provides insights into network collapse and robustness across various domains.
  • Findings challenge the notion that network decline is merely the inverse of network growth.