Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Signaling in Plants01:25

Cell Signaling in Plants

Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
Activation and Inactivation of G Proteins01:22

Activation and Inactivation of G Proteins

Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high affinity and are together...
Yeast Signaling01:28

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
Overview of Cell Signaling01:23

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Gene Regulation During Sporulation01:17

Gene Regulation During Sporulation

Sporulation is a complex developmental process that allows certain Gram-positive bacteria, such as Bacillus subtilis and Clostridium species, to survive extreme environmental conditions. This process is tightly regulated by a series of signaling cascades and transcriptional controls, ensuring the formation of a highly resistant endospore.Sporulation is triggered by unfavorable conditions, such as nutrient depletion, and is governed by a phosphorelay system. One of the sensor kinases, such as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impaired Lung BCAA Metabolism Promotes Ferroptosis and Resultant Pulmonary Arterial Hypertension-Associated Hepatopathy.

JACC. Basic to translational science·2026
Same author

Pulmonary arterial hypertension induces a metabolic and inflammatory hepatopathy.

The Journal of clinical investigation·2026
Same author

17β-Estradiol counteracts pathological microtubule remodeling to enhance right ventricular function in preclinical models.

The Journal of clinical investigation·2026
Same author

Multimodality Molecular Profiling Nominates Targetable Mechanisms in Progressive RV Dysfunction.

bioRxiv : the preprint server for biology·2026
Same author

Pulmonary Arterial Hypertension Induces a Metabolic and Inflammatory Hepatopathy.

bioRxiv : the preprint server for biology·2026
Same author

GP130 Antagonism Enhances Porcine RV Function.

Circulation research·2025

Related Experiment Video

Updated: Jun 28, 2026

Visualizing Cellular Gibberellin Levels Using the nlsGPS1 Förster Resonance Energy Transfer (FRET) Biosensor
08:53

Visualizing Cellular Gibberellin Levels Using the nlsGPS1 Förster Resonance Energy Transfer (FRET) Biosensor

Published on: January 12, 2019

Gibberellin signaling.

Lynn M Hartweck1

  • 1Department of Plant Biology, 250 Biological Sciences Center, 1445 Gortner Ave, St Paul, MN 55108, USA. hartw006@umn.edu

Planta
|October 22, 2008
PubMed
Summary

Gibberellin (GA) signaling involves DELLA proteins that regulate growth by interacting with GA receptors (GID1) and light signaling factors (PIFs). GA induces growth by degrading DELLAs, integrating light and hormone pathways.

Area of Science:

  • Plant biology
  • Molecular signaling
  • Hormone regulation

Background:

  • Gibberellin (GA) signaling is a crucial plant growth regulator.
  • DELLA proteins act as negative regulators in GA response pathways.
  • The GIBBERELLIN INSENSITIVE DWARF 1 (GID1) receptor plays a central role in GA perception.

Purpose of the Study:

  • To review recent advances in understanding gibberellin (GA) signaling mechanisms.
  • To elucidate the molecular interactions governing GA response.
  • To explore the evolutionary context of GA signaling.

Main Methods:

  • Review of recent scientific literature on GA signaling.
  • Analysis of structural data for GID1.
  • Examination of evolutionary and sequence data from various plant species.

More Related Videos

Measuring Gene Expression in Bombarded Barley Aleurone Layers with Increased Throughput
10:29

Measuring Gene Expression in Bombarded Barley Aleurone Layers with Increased Throughput

Published on: March 30, 2018

Scalable, Flexible, and Cost-Effective Seedling Grafting
09:33

Scalable, Flexible, and Cost-Effective Seedling Grafting

Published on: January 6, 2023

Related Experiment Videos

Last Updated: Jun 28, 2026

Visualizing Cellular Gibberellin Levels Using the nlsGPS1 Förster Resonance Energy Transfer (FRET) Biosensor
08:53

Visualizing Cellular Gibberellin Levels Using the nlsGPS1 Förster Resonance Energy Transfer (FRET) Biosensor

Published on: January 12, 2019

Measuring Gene Expression in Bombarded Barley Aleurone Layers with Increased Throughput
10:29

Measuring Gene Expression in Bombarded Barley Aleurone Layers with Increased Throughput

Published on: March 30, 2018

Scalable, Flexible, and Cost-Effective Seedling Grafting
09:33

Scalable, Flexible, and Cost-Effective Seedling Grafting

Published on: January 6, 2023

Main Results:

  • GA signaling hinges on DELLA proteins, which regulate gene expression and interact with GA receptors (GID1).
  • GA binding to GID1 promotes DELLA degradation via the proteasome, leading to growth.
  • DELLA proteins integrate light and GA signaling by interacting with PHYTOCHROME INTERACTING FACTOR (PIF) proteins.

Conclusions:

  • GA-induced growth is mediated by the degradation of DELLA repressors.
  • The integration of light and GA pathways by DELLAs and PIFs fine-tunes growth responses.
  • GA signaling likely evolved early in plant evolution, preceding seed reproduction.