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Related Experiment Video

Updated: Jun 28, 2026

Perceptual and Category Processing of the Uncanny Valley Hypothesis' Dimension of Human Likeness: Some Methodological Issues

Perceptual and Category Processing of the Uncanny Valley Hypothesis' Dimension of Human Likeness: Some Methodological Issues

Published on: June 3, 2013

Recognition of intercenter differences may help develop best practice.

Rut Norda¹, Claes Göran Axelsson, Ulla Axdorph

¹Department of Clinical Immunology and Transfusion Medicine, Uppsala University Hospital, Uppsala, Sweden. rut.norda@akademiska.se

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

|October 22, 2008

Summary

This study analyzed adverse effects (AE) from plasma exchange (PE) procedures in Sweden. Significant intercenter variations in AE frequency and symptoms were found, prompting practice improvements.

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Area of Science:

Medical Science
Clinical Practice
Quality Improvement

Background:

The Swedish Apheresis Registry collects data for national quality improvement.
Intercenter comparisons are crucial for identifying best practices in apheresis procedures.

Purpose of the Study:

To evaluate differences in adverse effects (AE) associated with plasma exchange (PE).
To identify variations in AE frequency and symptoms across different Swedish university hospital centers.
To inform the development of best practices for PE.

Main Methods:

Analysis of 620 AE reports from 12,461 PE procedures (1996-2002).
Comparison of AE data from eight Swedish university hospital centers.
Statistical analysis of AE frequencies in relation to patient conditions and centers.

Main Results:

Overall AE rate remained stable, but prematurely interrupted procedures decreased (2.1% to 1.3%).
Mean frequency of moderate to severe AE was 5%.
AE rates varied significantly by indication (GBS 10%, TTP-HUS 8%, Macroglobulinemia 2%) and between centers (four-fold difference).

Conclusions:

Significant intercenter variations in PE-related AE exist.
Differences in indications and substitution fluids may contribute to AE variability.
Study findings have initiated practice changes to improve PE procedures and patient safety.