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Automated assessment of ovarian follicles using a novel three-dimensional ultrasound software

Todd D Deutch¹, Iris Joergner, David O Matson

¹Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA. deutchtd@evms.edu

Fertility and Sterility

|October 22, 2008

Abstract

Objective:

To evaluate the accuracy, efficiency, and applicability of a new automated method of follicular assessment.

Design:

Retrospective review of three-dimensional ultrasonographic ovarian volumes.

Setting:

Academic center.

Patient(S):

Three-dimensional ovarian volumes from patients undergoing IVF.

Intervention(S):

Three-dimensional volumes of gonadotropin-stimulated ovaries and simulated ovarian follicles (SOFs) of known volume were evaluated with the new automated follicular assessment software (SonoAVC).

Main Outcome Measure(S):

[1] Maximum absolute error for the SonoAVC in assessing the volumes of the SOFs; [2] correlations between the automated and manual follicular measurements; [3] time required to analyze all of the follicles in a given ovarian volume.

Result(S):

The SOF of 4, 6, and 10 mm were evaluated. The SonoAVC's maximum absolute error for the volumes of the 4, 6, and 10 mm SOFs was 0 (0%), 0.01 (8.3%), and 0.02 (3.8%) cc, respectively. Three hundred forty-seven follicles, ranging in diameter from 2.3-32 mm, were evaluated. The correlation coefficient for the SonoAVC-generated relaxed follicular diameter and the manual measured mean follicular diameter was 0.99. The time required to analyze all of the follicles in a given ovarian volume for the automated and manual method was 133 versus 361 seconds, respectively.

Conclusion(S):

The SonoAVC proved to be a very accurate and efficient way to measure ovarian follicles. The measurements obtained by the SonoAVC correlated extremely well with the manual measurements we obtained.

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