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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

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Increased extent of object-selective cortex in schizophrenia.

Jonathan K Wynn¹, Michael F Green, Stephen Engel

¹Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA. jkwynn@ucla.edu

Psychiatry Research

|October 22, 2008

Summary

Schizophrenia patients show normal brain activity amplitude in early visual areas. However, object recognition areas (LO) display altered spatial organization in schizophrenia patients, impacting visual processing.

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Area of Science:

Neuroscience
Cognitive Neuroscience
Psychiatry

Background:

Schizophrenia is associated with visual information processing deficits.
Functional magnetic resonance imaging (fMRI) studies have begun to explore visual processing in schizophrenia.
Understanding early visual processing in schizophrenia remains incomplete.

Purpose of the Study:

To investigate the magnitude and spatial organization of brain activity in early visual processing areas in schizophrenia patients.
To compare activity in retinotopically organized areas (V1-V4), motion-sensitive areas (hMT+), and object-recognition areas (LO) between schizophrenia patients and controls.

Main Methods:

Utilized fMRI to measure regional brain activity.
Employed visual stimuli specifically designed to activate V1-V4, hMT+, and LO.
Compared brain responses in 22 schizophrenia patients and 19 healthy controls.

Main Results:

Activity amplitude was similar across all three visual areas in both groups.
Spatial overlap of activity was comparable for retinotopically organized areas and hMT+ between groups.
Activation in the lateral occipital complex (LO) was more widely distributed in schizophrenia patients compared to controls.

Conclusions:

Schizophrenia is characterized by normal amplitude but altered spatial organization in specific visual processing regions.
Abnormal spatial organization of the lateral occipital complex (LO) in schizophrenia may underlie object recognition deficits.
These findings contribute to understanding the neural basis of visual processing impairments in schizophrenia.