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Updated: Jun 28, 2026

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
Published on: May 10, 2013
Estimated glomerular filtration rate for drug dose adjustment: Cockcroft and Gault or abbreviated MDRD equation?
Isabelle Roblin1, Sophie De Sobarnitsky, Cécile Basselin
1Pharmacy Department, Valence Hospital, 26000 Valence, France. iroblin@ch-valence.fr
Objectives:
Evaluate if Cockcroft and Gault (CG) estimated glomerular filtration rate (eGFR) might be replaced by abbreviated MDRD eGFR for drug dose adjustment.
Design And Methods:
eGFR was determined in 140 hospitalized patients (median: 68 years, 65 kg) treated by nephrotoxic and/or renally cleared drugs.
Results:
CG eGFR was 61 mL/min vs. 78 mL/min/1.73 m(2) for MDRD (p<0.0001). CG-MDRD difference ranged from -93 to +34 mL/min, influenced by patient age, weight, and gender (p<0.001).
Conclusions:
CG eGFR cannot be easily replaced by abbreviated MDRD eGFR for drug dose adjustment.
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