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Updated: Jun 28, 2026

Skin Tattooing As A Novel Approach For DNA Vaccine Delivery
Published on: October 18, 2012
[Skin vaccination]
1Division of Quality Assurance, National Institute of Infectious Diseases.
Abstract:
Skin is an immunologically active organ composed of various immunocompetent cells and draining lymph nodes. Especially, Langerhans cells(LCs) are located in the outer layer of the skin and play the role of sentinels. Therefore, LCs could be an ideal targets of vaccination. Recently, many studies have demonstrated that the topical application of antigens on the skin induced both humoral and cellular immune responses. This emerging needle-free vaccination route would have various clinical merits and could be highly promising.
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