Related Experiment Video
Updated: Jun 28, 2026
08:46
Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
Published on: May 18, 2016
[Malaria vaccine].
1Department of Protozoology, Research Institute for Microbial Diseases, Osaka Univesity.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|October 23, 2008
Summary
Malaria vaccine development using the SE36 protein shows promise. This Plasmodium falciparum antigen, BK-SE36, demonstrated safety and immunogenicity in clinical trials, offering hope against malaria.
Area of Science:
- Infectious Diseases
- Vaccinology
- Parasitology
Context:
- Malaria remains a significant global health threat, affecting billions worldwide.
- Existing control strategies are insufficient, highlighting the urgent need for effective vaccines.
- Plasmodium falciparum is the deadliest malaria parasite species.
Purpose:
- To develop a novel malaria vaccine candidate targeting the Plasmodium falciparum SE36 protein.
- To evaluate the safety and immunogenicity of the BK-SE36 vaccine formulation.
- To assess the protective efficacy of the vaccine in preclinical and clinical studies.
Summary:
- The SE36 protein, derived from the N-terminal domain of Plasmodium falciparum Serine Repeat Antigen (SERA5), was developed as a vaccine candidate.
- Immunoepidemiological studies indicate a strong correlation between naturally induced antibodies to SE36 and protective immunity.
- The GMP-grade vaccine, BK-SE36 (SE36 adsorbed to aluminum hydroxide gel), demonstrated significant protection in squirrel monkeys and was found to be safe and highly immunogenic in a Phase Ia clinical trial in healthy adults.
Impact:
- The BK-SE36 vaccine shows potential as a safe and effective tool for malaria control.
- Positive clinical trial results support further development of SE36-based malaria vaccines.
- This research contributes to the global effort to combat malaria and reduce its public health burden.
Related Concept Videos
01:29Malaria
Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
00:58Symbiosis
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
01:51Vaccinations
Overview
01:18Yellow Fever
Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
01:17Poliomyelitis
Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
01:21Vaccines
Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...