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Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...

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Related Experiment Video

Updated: Jun 28, 2026

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

[Dengue vaccines].

Kouichi Morita¹

¹Department of Virology, Institute of Tropical Medicine, Nagasaki University.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|October 23, 2008

Summary

Global warming may expand dengue fever's reach, necessitating new vaccines. Current live-attenuated tetravalent vaccines require careful safety evaluation due to potential antibody-dependent enhancement risks.

Area of Science:

Tropical infectious diseases
Virology
Vaccinology

Context:

Dengue virus is a major tropical mosquito-borne illness.
Global warming is projected to increase dengue epidemic areas.
Urgent need for effective and affordable dengue vaccines exists.

Purpose:

To review the status of dengue vaccine development.
To highlight the risks associated with live-attenuated tetravalent vaccines.
To emphasize the need for rigorous safety assessments.

Summary:

Live-attenuated tetravalent vaccines are in development, with two candidates in Phase II trials.
A significant concern is the potential for antibody-dependent enhancement (ADE) of infection.
Further research is crucial to fully understand and mitigate ADE risks.

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Last Updated: Jun 28, 2026

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen

Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen

Published on: January 26, 2024

Impact:

Informed vaccine development strategies for dengue.
Guidance for regulatory bodies on vaccine safety evaluation.
Potential for improved public health outcomes in dengue-endemic regions.