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Hiatal Hernia

Hiatal Hernia

A hiatal hernia is the abnormal protrusion of the stomach or other abdominal organs through the esophageal hiatus of the diaphragm into the thoracic cavity.Normally, the gastroesophageal junction (GEJ) lies below the diaphragm and is supported by the phrenoesophageal membrane, the diaphragmatic crura, and connective tissues. Weakening of these structures—due to aging, congenital defects like a short esophagus, or increased intra-abdominal pressure from coughing, obesity, pregnancy, or heavy...

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Esophageal Achalasia

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Related Experiment Video

Updated: Jun 28, 2026

Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review

Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review

Published on: November 8, 2024

[Hernias as medical disease].

Jakob Burcharth¹, Jacob Rosenberg

¹Strandboulevarden 97, st. mf., DK-2100 København Ø. jakobburcharth@gmail.com

Ugeskrift for Laeger

|October 23, 2008

Summary

Abnormal collagen metabolism, specifically a low type-I/III collagen ratio, increases hernia risk. Understanding a patient's collagen profile may personalize surgical hernia repair.

Area of Science:

Biochemistry
Genetics
Surgical Pathology

Context:

Systemic collagen metabolism plays a crucial role in tissue integrity.
Hernias are associated with abnormalities in connective tissue.
A reduced type-I/III collagen ratio is a documented risk factor for hernias.

Purpose:

To investigate the link between collagen metabolism and hernia development.
To identify patient groups at increased risk due to collagen profiles.
To explore personalized surgical approaches based on collagen status.

Summary:

Abnormal systemic collagen metabolism, characterized by a reduced type-I/III collagen ratio, is implicated in hernia development.
Conditions such as Ehlers-Danlos syndrome, Marfan syndrome, and abdominal aortic aneurysms share this collagen abnormality.

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Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review

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Laparoscopic Repair of Para-Esophageal Hernia Using Absorbable Biosynthetic Mesh

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Published on: September 11, 2021

This highlights a potential biomarker for herniation risk and informs tailored treatment strategies.

Impact:

Provides insight into the molecular basis of hernia formation.
Identifies specific patient cohorts with elevated herniation risk.
Suggests a future direction for individualized surgical interventions in hernia repair.