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Cervical mucus score and in vitro sperm mucus interaction in spontaneous and clomiphene citrate cycles
1Department of Obstetrics and Gynaecology, University of Aberdeen, Maternity Hospital, Scotland.
Objective:
Assessment of the effects of clomiphene citrate (CC) on cervical mucus score and in vitro sperm mucus interaction.
Design:
Prospective study of cervical mucus score and in vitro sperm mucus interaction in a spontaneous cycle followed by a CC cycle to compare paired data.
Setting:
Tertiary institutional infertility clinic.
Patients, Participants:
Twenty-two couples with primary unexplained infertility were studied in both cycles.
Interventions:
Clomiphene citrate (150 mg) on days 5 to 9 in CC cycles.
Main Outcome Measures:
Cervical mucus score and sperm-mucus penetration test score.
Results:
Mean cervical mucus score in spontaneous cycles was 9.3 (95% confidence interval [CI] 8.4 to 10.2) and in CC cycles 5.6 (95% CI 4.6 to 6.6), P less than 0.0001. Sperm-mucus penetration test score in spontaneous cycles was 11.4 (95% CI 7.6 to 15.2) and in CC cycles 3.9 (95% CI 1.17 to 6.63), P less than 0.01.
Conclusions:
Clomiphene citrate has an adverse effect on both cervical mucus score and sperm-mucus penetration.