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Changes in body composition with danazol therapy.

R Bruce1, B Lees, S I Whitcroft

  • 1Wynn Institute for Metabolic Research, London, United Kingdom.

Fertility and Sterility
|September 1, 1991
PubMed
Summary
This summary is machine-generated.

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Danazol treatment for endometriosis increased lean body mass and decreased fat mass, with greater fat loss in the lower body compared to the upper body. This study highlights danazol

Area of Science:

  • Endocrinology
  • Reproductive Medicine
  • Body Composition Analysis

Background:

  • Endometriosis is a common gynecological condition.
  • Danazol is a medication used to treat endometriosis.
  • Understanding the effects of danazol on body composition is important for patient management.

Purpose of the Study:

  • To investigate the effects of danazol on whole body lean and fat mass in premenopausal women with endometriosis.
  • To assess regional body fat distribution changes during danazol treatment.

Main Methods:

  • 14 premenopausal women with endometriosis were treated with danazol.
  • Whole body lean and fat mass were measured using dual-energy x-ray absorptiometry (DXA).
  • Measurements were taken before and after 6 months of danazol treatment.

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Main Results:

  • A significant increase in lean tissue mass was observed after 6 months of danazol treatment.
  • Overall body fat decreased, but the reduction was less pronounced in the android (upper body) region compared to the gynoid (lower body) region.
  • Dual-energy x-ray absorptiometry proved to be a noninvasive and rapid method for body composition assessment.

Conclusions:

  • Danazol exhibits both anabolic and androgenic effects on body composition in women with endometriosis.
  • The drug influences lean mass accretion and fat redistribution.
  • DXA is a valuable tool for monitoring these changes.