Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Niche

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

Cellular Differentiation

Cellular Differentiation

How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Lineage Commitment

Lineage Commitment

Commitment is the process whereby stem cells:

Multipotency and Niche of Bulge Stem Cell

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Progressive matrix stiffening of tyramine-modified silk fibroin hydrogels governs stage-specific pulmonary fibroblast activation.

bioRxiv : the preprint server for biology·2026

Same author

Modeling ventricular tachycardia in genetic long QT syndrome using engineered cardiac tissues.

Bioactive materials·2026

Same author

Human iPSC-derived macrophages for studying intrinsic and extrinsic factors in cystic fibrosis.

EXO : beyond the cell·2026

Same author

A Simple, Robust Method for Cellular Electrical Interfacing Using Molecular Patterning.

ACS applied materials & interfaces·2026

Same author

Avenues for optimization of cardiac therapeutics by minimally invasive delivery.

Acta biomaterialia·2026

Same author

A custom preservation solution extends the ex vivo availability of living heart valves for transplantation.

JTCVS open·2025

Search research articles

Related Experiment Video

Updated: Jun 28, 2026

Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates

Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates

Published on: June 17, 2016

Patterning stem cell differentiation.

Gordana Vunjak-Novakovic¹

¹Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, Mail Code 8904, New York, NY 10027, USA. gv2131@columbia.edu

|October 23, 2008

Summary

This study explores geometric-force control in stem cell differentiation. It offers a new approach to understanding how physical forces regulate cell development and tissue assembly.

Area of Science:

Developmental Biology
Stem Cell Biology
Biophysics

Background:

Understanding the regulation of cell differentiation and tissue assembly is crucial in developmental biology.
Previous research has focused on genetic and molecular mechanisms, with less emphasis on physical forces.

Discussion:

The Chen laboratory presents a novel approach to investigate the role of physical forces in controlling stem cell differentiation.
This method allows for a deeper examination of how geometric constraints and mechanical forces influence cell fate decisions.

Key Insights:

Geometric-force control is a significant factor in stem cell differentiation.
The study provides a framework for dissecting the interplay between physical cues and cellular processes.

More Related Videos

Patterning of Embryonic Stem Cells Using the Bio Flip Chip

Patterning of Embryonic Stem Cells Using the Bio Flip Chip

Published on: October 1, 2007

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

Related Experiment Videos

Last Updated: Jun 28, 2026

Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates

Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates

Published on: June 17, 2016

Patterning of Embryonic Stem Cells Using the Bio Flip Chip

Patterning of Embryonic Stem Cells Using the Bio Flip Chip

Published on: October 1, 2007

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

Outlook:

This research opens new avenues for regenerative medicine and tissue engineering.
Future studies can build upon this approach to explore complex developmental processes and disease mechanisms.