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Delayed plasticity of inhibitory neurons in developing visual cortex.

Sunil P Gandhi1, Yuchio Yanagawa, Michael P Stryker

  • 1Keck Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, CA 94143-0444, USA. sunil@phy.ucsf.edu

Proceedings of the National Academy of Sciences of the United States of America
|October 23, 2008
PubMed
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Inhibitory cells in the visual cortex show delayed plasticity during development. This delay in inhibitory plasticity accelerates learning in neighboring excitatory neurons.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Visual System Research

Background:

  • Sensory experience drives rapid changes in the neocortex during development.
  • Intracortical inhibition disruptions impair experience-dependent plasticity.
  • The plasticity of inhibitory cells during these processes remains poorly understood.

Purpose of the Study:

  • To investigate the temporal dynamics of inhibitory cell plasticity in the mouse visual cortex.
  • To understand how inhibitory cell responses change relative to excitatory cells during monocular deprivation.

Main Methods:

  • Functional two-photon microscopy for single-cell resolution imaging.
  • Genetic identification of inhibitory and excitatory cell types.
  • Monocular visual deprivation in mice.

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Published on: September 20, 2024

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Main Results:

  • Initially, inhibitory and excitatory cells showed similar binocular responses.
  • After 2 days of monocular deprivation, excitatory cells adapted to the open eye, while inhibitory cells favored the deprived eye.
  • By 4 days, inhibitory cell responses realigned with excitatory cell changes, revealing a plasticity delay.

Conclusions:

  • Inhibitory cell plasticity in the visual cortex is significantly delayed compared to excitatory cells.
  • This delay in inhibitory plasticity accelerates Hebbian plasticity in adjacent excitatory neurons.
  • Provides a network-level mechanism for how inhibition governs neocortical plasticity.