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Updated: Jun 28, 2026

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Published on: April 6, 2015

Basophil effector function and homeostasis during helminth infection.

Caspar Ohnmacht¹, David Voehringer

¹Institute for Immunology, University of Munich, Munich, Germany.

|October 23, 2008

Summary

Basophils, key innate immune cells, are crucial for fighting parasitic worm infections. This study reveals their development, lifespan, and critical role in type 2 immune responses for efficient parasite expulsion.

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Area of Science:

Immunology
Cell Biology
Parasitology

Background:

Basophils are innate immune cells linked to allergic inflammation and parasitic infections.
Their development, in vivo functions, and tissue localization remain largely uncharacterized.

Purpose of the Study:

To investigate basophil development, lifespan, tissue distribution, and effector functions during helminth infection.
To elucidate the role of basophils in type 2 immune responses against Nippostrongylus brasiliensis.

Main Methods:

Characterization of basophil development and turnover.
Analysis of basophil tissue localization in spleen, intestine, and lungs.
Assessment of basophil-mediated immune responses, including eosinophilia and macrophage differentiation.

Main Results:

Basophils have a lifespan of approximately 60 hours under homeostatic conditions.
Nippostrongylus brasiliensis infection induces increased basophil production in the bone marrow.
Basophils are found in specific splenic, intestinal, and lung tissues and promote eosinophilia and alternatively activated macrophages.

Conclusions:

Basophils are essential effector cells in type 2 immune responses.
Activated basophils contribute significantly to efficient expulsion of helminth parasites.
This study clarifies basophil roles in immunity against parasitic infections.