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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Related Experiment Video

Updated: Jun 28, 2026

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
16:10

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins

Published on: March 22, 2012

TCR complex-activated CD8 adhesion function by human T cells.

Jay C Varghese1, Kevin P Kane

  • 1Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.

Journal of Immunology (Baltimore, Md. : 1950)
|October 23, 2008
PubMed
Summary
This summary is machine-generated.

In human CD8(+) T cells, T cell receptor (TCR) signaling activates CD8 adhesion to MHC-I molecules, enhancing cell binding. This activated CD8 adhesion is present in differentiated T cells but not naive ones.

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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

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Last Updated: Jun 28, 2026

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
16:10

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins

Published on: March 22, 2012

Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist
07:48

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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Medicine

Background:

  • The CD8 coreceptor is crucial for CD8(+) T cell recognition of virally infected and malignant cells.
  • CD8 functions with the T cell receptor (TCR) to bind antigen-specific Major Histocompatibility Complex class I (MHC-I) molecules, initiating T cell activation.
  • The adhesive capacity of CD8 for non-antigenic MHC-I in humans remains largely uncharacterized.

Purpose of the Study:

  • To investigate the adhesive function of CD8 in human CD8(+) T cells.
  • To determine if TCR signaling can activate CD8 adhesion to MHC-I.
  • To compare CD8 adhesion in naive versus differentiated human CD8(+) T cells and explore species-specific differences.

Main Methods:

  • Utilized human CD8(+) T cells, including naive, effector/memory, and in vitro generated cytotoxic T lymphocytes (CTLs).
  • Investigated CD8-MHC-I interactions under shear conditions following T cell receptor (TCR) complex activation.
  • Examined the signaling pathways and kinetics governing activated CD8 adhesion.

Main Results:

  • TCR complex signaling activates CD8 adhesion molecule function in human CD8(+) T cells.
  • Activated CD8 engages MHC-I, enabling stable T cell adhesion under shear stress.
  • This activated adhesion was observed in differentiated T cells (CTLs, effector/memory) but not in naive CD8(+) T cells.
  • Differences in kinetics and signaling were noted compared to murine CD8 function.

Conclusions:

  • Activated CD8 adhesion, triggered by TCR signaling, contributes to firm T cell binding to target cells.
  • This mechanism is functional in differentiated CD8(+) T cells, potentially enhancing pathogen-infected cell clearance.
  • The findings highlight a distinct role for CD8 as an adhesion molecule regulated by TCR activation in humans.