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Transcription factor Gfi1 restricts B cell-mediated autoimmunity

Chozhavendan Rathinam1, Hans Lassmann, Michael Mengel

  • 1Department of Pediatric Hematology/Oncology, Hannover Medical School, Hannover, Germany.

Journal of Immunology (Baltimore, Md. : 1950)
|October 23, 2008
PubMed
Summary

Growth factor-independent-1 (Gfi1) deficiency in mice leads to autoimmunity. Gfi1-deficient B cells hyperproliferate, causing autoantibody production and organ damage, highlighting Gfi1 as a key regulator against autoimmunity.

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