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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

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Updated: Jun 28, 2026

Using Low-Cost Dyes to Visualize Glycogen Accumulation and Gut Integrity in Caenorhabditis elegans
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Using Low-Cost Dyes to Visualize Glycogen Accumulation and Gut Integrity in Caenorhabditis elegans

Published on: February 23, 2024

Celiac disease in the elderly.

Matthew W Johnson1, H Julia Ellis, Max A Asante

  • 1Royal Surrey Hospital, London, UK.

Nature Clinical Practice. Gastroenterology & Hepatology
|October 23, 2008
PubMed
Summary
This summary is machine-generated.

Celiac disease affects many, especially older adults. Early diagnosis and a gluten-free diet in elderly patients improve outcomes and reduce cancer risks.

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Last Updated: Jun 28, 2026

Using Low-Cost Dyes to Visualize Glycogen Accumulation and Gut Integrity in Caenorhabditis elegans
08:29

Using Low-Cost Dyes to Visualize Glycogen Accumulation and Gut Integrity in Caenorhabditis elegans

Published on: February 23, 2024

Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Geriatrics

Background:

  • Celiac disease affects 1 in 200 people in Europe and America.
  • Diagnosis rates have increased due to improved serological testing.
  • Up to 34% of newly diagnosed patients are over 60.

Purpose of the Study:

  • To highlight age-related differences in celiac disease presentation and investigation.
  • To increase physician awareness of celiac disease in the elderly population.
  • To emphasize the importance of early diagnosis and gluten-free diet compliance in older adults.

Main Methods:

  • Review of current literature on celiac disease in the elderly.
  • Analysis of age-related clinical presentations.
  • Discussion of diagnostic challenges and management strategies.

Main Results:

  • Elderly patients may present with subtle symptoms, delaying diagnosis.
  • Delayed diagnosis can lead to secondary complications.
  • A strict gluten-free diet is achievable and beneficial for elderly patients.

Conclusions:

  • Physicians must consider celiac disease in elderly patients due to its prevalence and potential for serious complications.
  • Early diagnosis and adherence to a gluten-free diet can mitigate risks of morbidity, cancer, and lymphoma.
  • Understanding age-related differences is crucial for effective management of celiac disease in older adults.