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Related Experiment Video

Updated: Jun 28, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

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Published on: November 23, 2014

Angiogenesis in pre-malignant conditions.

S R Menakuru¹, N J Brown, C A Staton

¹Microcirculation Research Group, Academic Surgical Oncology Unit, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield S10 2JF, UK.

British Journal of Cancer

|October 23, 2008

Summary

Angiogenesis, the formation of new blood vessels, starts before cancer becomes invasive. Inhibiting this process, known as angioprevention, could stop cancer progression.

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Area of Science:

Oncology
Vascular Biology
Cancer Prevention

Background:

Human studies indicate angiogenesis occurs in pre-malignant lesions.
Angiogenesis is a critical process in cancer development and progression.
Targeting angiogenesis may prevent the transition to invasive cancer.

Purpose of the Study:

To explore the potential of inhibiting angiogenesis for cancer prevention.
To understand the mechanisms driving angiogenesis in pre-cancerous conditions.
To identify key pathways for developing angioprevention strategies.

Main Methods:

Review of human studies on angiogenesis in pre-malignant lesions.
Analysis of mechanisms inducing angiogenesis.
Identification of critical factors in human tumorigenesis.

Main Results:

Evidence suggests angiogenesis is an early event in cancer development.
Inhibiting angiogenesis shows potential for preventing invasive cancer.
Understanding these mechanisms is crucial for therapeutic development.

Conclusions:

Angiogenesis is a viable target for cancer prevention strategies.
Further research into angiogenic mechanisms is needed for effective angioprevention.
Translational strategies are required to achieve the goal of angioprevention.