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Updated: Jun 28, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Trifluoromethyl ethers--synthesis and properties of an unusual substituent
Frédéric R Leroux1, Baptiste Manteau, Jean-Pierre Vors
1Laboratoire de Stéréochimie, Université Louis Pasteur (ECPM), CNRS, 25 rue Becquerel, F - 67087 Strasbourg Cedex 2, France. frederic.leroux@ecpm.u-strasbg.fr
Abstract:
After nitrogen, fluorine is probably the next most favorite hetero-atom for incorporation into small molecules in life science-oriented research. This review focuses on a particular fluorinated substituent, the trifluoromethoxy group, which is finding increased utility as a substituent in bioactives, but it is still perhaps the least well understood fluorine substituent in currency. The present review will give an overview of the synthesis, properties and reactivity of this important substituent.
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