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An Introduction to Aging and Regeneration

An Introduction to Aging and Regeneration

Tissues are maintained through a balance of cellular aging and regeneration. Aging refers to the gradual loss of cellular function, and regeneration is the repair of damaged tissue generally mediated by preexisting adult or somatic stem cells. Scientists are interested in understanding the biological mechanisms behind these two complex processes. By doing so, researchers may be able to use somatic stem cells to treat degenerative diseases and develop therapies that could delay the effects of...

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Related Experiment Video

Updated: Jan 20, 2026

Aging, Regeneration and Telomerase Activity

Aging, Regeneration and Telomerase Activity

Published on: April 29, 2023

Aging.

Samantha Galluzzi¹, Alberto Beltramello, Massimo Filippi

¹LENITEM - Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|November 15, 2008

Summary

This summary is machine-generated.

Aging significantly alters brain structure, impacting gray and white matter volume. Advanced magnetic resonance (MR) techniques help distinguish normal age-related changes from neurodegenerative diseases in older adults.

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Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

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Last Updated: Jan 20, 2026

Aging, Regeneration and Telomerase Activity

Aging, Regeneration and Telomerase Activity

Published on: April 29, 2023

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

Area of Science:

Neuroimaging
Gerontology
Neurology

Background:

The aging brain exhibits significant morphological changes.
Differentiating normal aging from neurodegenerative diseases is crucial for elderly brain health.
Noninvasive imaging, particularly magnetic resonance (MR), has advanced the study of brain aging.

Purpose of the Study:

To review studies on the effects of aging on brain structure.
To highlight the role of advanced MR techniques in assessing age-related brain changes.
To differentiate normal age-related brain variations from neurodegenerative conditions.

Main Methods:

Review of studies utilizing advanced magnetic resonance (MR) techniques.
Analysis of macro- and microstructural brain changes.
Assessment of global and regional gray and white matter volume changes.

Main Results:

Aging leads to considerable morphological changes in the adult brain.
Advanced MR techniques enable sophisticated analysis of brain images.
Studies assess the impact of aging on gray and white matter volume.

Conclusions:

Understanding age-related brain changes is vital for clinical diagnosis.
Advanced MR imaging is instrumental in studying brain structure and aging.
Continued research is needed to refine the understanding of brain aging.