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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

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Updated: Jun 28, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Tumours.

Andrea Falini1, Andrea Romano, Alessandro Bozzao

  • 1Neuroradiology Unit and CERMAC Scientific Institute and University San Raffaele, Via Olgettina 60, 20132 Milan, Italy. falini.andrea@hsr.it

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|November 15, 2008
PubMed
Summary
This summary is machine-generated.

Detecting brain lesions is crucial for diagnosing brain tumors. Advanced neuroimaging, particularly magnetic resonance imaging (MRI), now characterizes tumors and predicts prognosis.

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Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

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Area of Science:

  • Neurology
  • Radiology
  • Oncology

Background:

  • Brain lesion detection is the initial diagnostic step for suspected brain tumors.
  • Neuroradiological imaging is the primary tool for evaluating brain lesions.
  • Morphological imaging alone has limitations in fully characterizing brain lesions and determining malignancy grade.

Purpose of the Study:

  • To highlight the evolution of neuroimaging as a diagnostic tool for brain tumors.
  • To emphasize the importance of characterizing tumor type and grade.
  • To showcase the role of advanced imaging in assessing treatment response and prognosis.

Main Methods:

  • Utilizing neuroradiological imaging for initial diagnosis.
  • Employing advanced magnetic resonance imaging (MRI) techniques.
  • Integrating morphological and biological imaging for comprehensive characterization.

Main Results:

  • Neuroimaging has evolved into a comprehensive diagnostic tool.
  • Advanced MRI allows for detailed characterization of brain tumors.
  • Imaging aids in grading malignancy, monitoring treatment, and assessing prognosis.

Conclusions:

  • Early detection and characterization of brain lesions are vital.
  • Advanced neuroimaging, especially MRI, is essential for accurate brain tumor diagnosis and management.
  • Comprehensive imaging improves patient prognosis assessment and treatment monitoring.