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Updated: Jun 28, 2026

Assessing Transmissible Spongiform Encephalopathy Species Barriers with an In Vitro Prion Protein Conversion Assay
Published on: March 10, 2015
Complete genomic sequence of the goat prion protein gene (PRNP)
Mario Van Poucke1, Nicolas Willemarck, Karine Hugot
1Department of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine, Ghent University, 9820, Merelbeke, Belgium Mario.VanPoucke@UGent.be
Abstract:
Prion protein genetics plays a central role in transmissible spongiform encephalopathies, a disease occurring in human and animals. Here we report a 27-kb genomic sequence containing the goat PRNP gene. It shows, both in structure and content, a remarkable similarity with its sheep ortholog and can serve as a basis for future (comparative) studies with reference to the regulation of PRNP gene expression and the search for genetic tools to prevent/control/eradicate (goat) TSE.
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