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Psychosocial factors, exercise, and immunity: athletes, elderly persons, and AIDS patients
1Veterans Affairs Medical Center, Sepulveda, CA.
Abstract:
Maximal bicycle ergometry exercise increases natural killer (NK) cell activity and numbers in both healthy old and young persons to equivalent degree but with greater variability in the old. Exercise-induced increase in NK activity, but not numbers, is blocked by the opioid antagonist naloxone. Lactating females do not show exercise-induced augmentation of NK cell activity. A predisposition to autoimmune disease, particularly rheumatoid arthritis, may exist among athletes, and disease may ensue when athleticism ceases. Long-term survivors with AIDS generally engage in physical fitness/exercise programs.
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