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Drug interaction between rifampin and nortriptyline: a case report
1St. Michael's Hospital, Toronto, Canada.
International Journal of Psychiatry in Medicine
|January 1, 1991
Summary
Rifampin significantly reduces nortriptyline levels, requiring higher doses. Discontinuing rifampin can lead to toxic nortriptyline levels, necessitating close patient monitoring for drug interactions.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Drug Interactions
Background:
- Tricyclic antidepressants like nortriptyline are commonly prescribed for depression.
- Rifampin is a crucial antibiotic for treating tuberculosis.
- Potential drug interactions between these medications require investigation.