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Related Experiment Video

Updated: Jun 28, 2026

In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling

In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling

Published on: November 3, 2015

Cell volume regulation: physiology and pathophysiology.

I H Lambert¹, E K Hoffmann, S F Pedersen

¹Department of Biology, University of Copenhagen, Copenhagen, Denmark. ihlambert@bio.ku.dk

Acta Physiologica (Oxford, England)

|October 24, 2008

Summary

This summary is machine-generated.

Cell volume changes trigger signaling pathways for cell adaptation and function restoration. These volume changes are crucial signals in both normal physiology and disease states.

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Area of Science:

Cell Biology
Physiology
Pathophysiology

Background:

Cell volume perturbations activate intracellular signaling cascades, leading to adaptive responses and restoration of cellular function.
Cell volume challenges occur in various physiological (e.g., nutrient absorption, apoptosis) and pathophysiological (e.g., hypoxia, hyponatremia) conditions.
Increasing or decreasing cell volume can act as a specific signal regulating physiological processes like transport, migration, proliferation, and cell death.

Purpose of the Study:

To review recent advancements in understanding cell volume sensing mechanisms.
To highlight the relationship between cell volume regulation and organismal physiology and pathophysiology.

Main Methods:

Literature review of recent major developments in cell volume regulation research.
Emphasis on sensors, transducers, and effectors involved in converting volume changes into physiological responses.

Main Results:

Significant progress has been made in identifying sensors, transducers, and effectors of cell volume changes.
Cell volume regulation is intrinsically linked to broader physiological and pathophysiological processes.

Conclusions:

While sensing mechanisms are not fully elucidated, key components are being identified.
Cell volume regulation plays a critical role in maintaining organismal homeostasis and responding to disease.