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Related Concept Videos

Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Systemic sclerosis and cardiac dysfunction: evolving concepts and diagnostic methodologies.

Yannick Allanore1, Christophe Meune, André Kahan

  • 1Departments of Rheumatology A, France bCardiology, Paris Descartes University, Cochin Hospital, AP-HP, Paris, France. yannick.allanore@cch.aphp.fr

Current Opinion in Rheumatology
|October 24, 2008
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis commonly affects the heart, leading to fibrosis and poor prognosis. Early detection using echocardiography and other imaging techniques is crucial for managing cardiac involvement in scleroderma patients.

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Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

Area of Science:

  • Cardiology
  • Rheumatology
  • Medical Imaging

Background:

  • Systemic sclerosis frequently involves the heart, often due to repeated ischemic injury leading to myocardial fibrosis.
  • Clinically significant cardiac involvement is a marker of poor prognosis in systemic sclerosis.
  • Preclinical identification of cardiac involvement is essential for improved patient outcomes.

Purpose of the Study:

  • To review current methods for assessing cardiac involvement in systemic sclerosis.
  • To highlight the importance of early detection and risk stratification.
  • To discuss the role of various imaging modalities in managing myocardial complications.

Main Methods:

  • Echocardiography, including pulsed tissue Doppler, is a primary tool for cardiac assessment.
  • Single photon emission computed tomography (SPECT) can evaluate myocardial perfusion.
  • Cardiac magnetic resonance imaging (CMR) offers comprehensive assessment of cardiac function, perfusion, inflammation, and fibrosis.

Main Results:

  • Patients with systemic sclerosis and antitopoisomerase I antibodies are at higher risk for cardiac involvement.
  • Echocardiography and pulsed tissue Doppler are foundational for evaluating heart function.
  • CMR provides detailed insights into myocardial structure and function, aiding in diagnosis and management.

Conclusions:

  • A range of diagnostic methods are available, balancing research applications with routine clinical practice.
  • Conventional echocardiography, pulsed tissue Doppler, and natriuretic peptides are suitable for routine cardiac assessment in systemic sclerosis.
  • Advanced imaging like CMR complements traditional methods, enabling thorough evaluation of myocardial disease.