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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
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Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

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Updated: Jun 28, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

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The EULAR Scleroderma Trials and Research Group (EUSTAR): an international framework for accelerating scleroderma

Alan Tyndall1, Ulf M Ladner, Marco Matucci-Cerinic

  • 1Department of Rheumatology, University of Basel, Basel, Switzerland.

Current Opinion in Rheumatology
|October 24, 2008
PubMed
Summary

The European League Against Rheumatism Scleroderma Trials And Research group (EUSTAR) facilitates global systemic sclerosis research and patient care. EUSTAR

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Area of Science:

  • Rheumatology
  • Autoimmune Diseases
  • Clinical Research

Background:

  • Systemic sclerosis presents complex pathogenesis and varied clinical manifestations.
  • No specific curative treatment currently exists for systemic sclerosis.
  • The European League Against Rheumatism Scleroderma Trials And Research group (EUSTAR) was established to address these challenges.

Purpose of the Study:

  • To foster the study of systemic sclerosis globally.
  • To promote equitable assessment and care for systemic sclerosis patients worldwide.
  • To advance evidence-based principles in managing systemic sclerosis.

Main Methods:

  • Development of a minimal essential data set for patient tracking.
  • Establishment of international teaching courses for investigators.
  • Organization of 'teach the teachers' initiatives for standardized skin scoring.

Main Results:

  • Over 7000 patients registered across 150 centers on four continents.
  • Multiple publications utilizing data from the minimal essential data set.
  • Enhanced international networks among young investigators, improving multicenter trial quality.

Conclusions:

  • EUSTAR's influence and membership have expanded beyond Europe.
  • Growth in data and biomaterial collection supports future multicenter studies.
  • Financial sustainability is a critical concern for EUSTAR's continued operation and global impact.