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Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
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Rosai Dorfman disease.

M K Khan1, M K Khan, S Z Sultana

  • 1Department of pediatrics, Community Based Medical College, Mymensingh, Bangladesh. mmukkhan@gmail.com

Mymensingh Medical Journal : MMJ
|December 17, 2008
PubMed
Summary

Rosai-Dorfman disease, a rare benign condition, can affect lymph nodes and extra-nodal sites. This case report highlights a 14-year-old girl in Bangladesh diagnosed with this condition, showing gradual improvement with monitoring.

Area of Science:

  • Pathology
  • Oncology
  • Immunology

Background:

  • Rosai-Dorfman disease (RDD) is a rare, benign lymphoproliferative disorder.
  • Typically affects lymph nodes but can involve extranodal sites.
  • First described in 1969, RDD presents with characteristic histopathological findings.

Observation:

  • A 14-year-old female presented with gradual, painless massive cervical lymphadenopathy over six weeks.
  • Mild low-grade fever was noted, with no signs of acute inflammation.
  • Routine investigations excluded common causes of lymphadenopathy.

Findings:

  • Excisional biopsy and histopathology confirmed Rosai-Dorfman disease.
  • The patient exhibited a benign clinical course with gradual regression of lymph node size.

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  • Histopathology revealed characteristic features of RDD.

    • Implications:

    • This report is likely the first documented case of Rosai-Dorfman disease in Bangladesh.
    • Emphasizes the importance of considering RDD in the differential diagnosis of cervical lymphadenopathy.
    • Highlights the typically benign prognosis and conservative management approach for RDD.