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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Transitional cell carcinoma of the urinary bladder: a clinicopathological study
I Matalka1, K Bani-Hani, A Shotar
1Department of Pathology, Faculty of Medicine, King Abdulah University Hospital, Jordan University of Science and Technology, Irbid, Jordan. imatalka@hotmail.com
Singapore Medical Journal
|October 24, 2008
Summary
This study highlights bladder cancer features in Jordan, finding similar ages of presentation to Western countries but a higher male-to-female ratio. Stage at presentation was also comparable, though recurrence rates may be affected by follow-up duration.
Area of Science:
- Urology
- Oncology
- Public Health
Background:
- Urinary bladder cancer presents a significant health concern globally.
- Limited data exists on the clinicopathological features of bladder cancer in the Middle East.
- Jordan serves as a relevant model for understanding regional trends.
Purpose of the Study:
- To characterize the clinicopathological features of urinary bladder cancer in Jordan.
- To provide a regional perspective on bladder cancer presentation and management.
- To compare findings with international data.
Main Methods:
- Retrospective review of 115 bladder cancer patients managed between 1994-2000.
- Focus on Transitional Cell Carcinoma (TCC), comprising 110 cases.
- Analysis of patient demographics, tumor grade, pathological stage, and treatment modalities.
Main Results:
- The study included 115 patients (99 male, 11 female) with a mean age of 60.6 years.
- 60.9% of tumors were low-grade, and 54.5% were stage PTa.
- Treatment included transurethral resection (81 patients), with a 31.4% recurrence rate observed in surgically treated patients.
Conclusions:
- Transitional Cell Carcinoma in Jordan presents at a similar age to Western populations.
- A notably higher male-to-female ratio was observed in Jordanian patients.
- Stage at presentation aligns with Western data, but follow-up duration may influence observed recurrence rates.
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