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Related Experiment Video

Updated: Jun 28, 2026

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction

Published on: March 29, 2024

Systemic lupus erythematosus associated with extreme hypertriglyceridemia.

Chin-Sung Huang¹, Wei-Fong Wu

¹Department of Pediatrics, Taipei City Hospital Ren-Ai Branch, Taipei, Taiwan.

Pediatrics and Neonatology

|October 25, 2008

Summary

Systemic lupus erythematosus (SLE) can cause severe hypertriglyceridemia. Steroid treatment dramatically lowered triglycerides in a 13-year-old patient, suggesting a role for steroids in correcting lipoprotein lipase deficiency.

Related Experiment Videos

Last Updated: Jun 28, 2026

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction

Published on: March 29, 2024

Area of Science:

Immunology
Endocrinology
Genetics

Background:

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical manifestations.
Hypertriglyceridemia, particularly severe forms, is infrequently reported in SLE patients.
Lipoprotein lipase (LPL) plays a crucial role in triglyceride metabolism.

Observation:

A 13-year-old female with SLE presented with severe hypertriglyceridemia (5601 mg/dL).
Despite the severity, the hypertriglyceridemia was remarkably well tolerated clinically.
The patient's triglyceride levels normalized to 75 mg/dL following high-dose steroid therapy.

Findings:

Steroid treatment led to a dramatic reduction in serum triglycerides, irrespective of dietary changes.
The rapid normalization suggests steroids may directly or indirectly enhance lipoprotein lipase activity.
The potential presence of an autoantibody against lipoprotein lipase was considered, prompting immunosuppressive therapy.

Implications:

This case highlights a rare but significant association between SLE and severe hypertriglyceridemia.
Corticosteroids may represent a therapeutic option for managing hypertriglyceridemia in select SLE patients.
Further research is warranted to elucidate the precise mechanism by which steroids impact LPL activity in this context.