Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Pericardial Fat on Intracardiac Atrial Impedance and Generator Impedance.

Journal of arrhythmia·2026
Same author

Intravascular hemolysis after pulsed field ablation for atrial fibrillation: A comparative analysis of 3 systems.

Heart rhythm O2·2026
Same author

Outflow tract premature ventricular contraction ablation via an azygos continuation in a patient with interrupted inferior vena cava.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2026
Same author

Reversible ST-T Segment Changes Induced by Anamorelin: A Case Report.

Respirology case reports·2025
Same author

Validation of an automated premature ventricular contraction mapping algorithm.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2025
Same author

Species-specific gene expression manipulation in humanized livers of chimeric mice via siRNA-encapsulated lipid nanoparticle treatment.

Molecular therapy. Methods & clinical development·2025

Related Experiment Video

Updated: Jun 28, 2026

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
06:14

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

Occlusal hypofunction induces atrophic changes in rat gingiva.

Yuji Ishida1, Zuisei Kanno, Kunimichi Soma

  • 1Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. yjis.orts@tmd.ac.jp

The Angle Orthodontist
|October 25, 2008
PubMed
Summary
This summary is machine-generated.

Occlusal hypofunction disrupts gingival tissue structure and alters extracellular matrix biosynthesis. Key proteins, connective tissue growth factor (CTGF) and lysyl oxidase (LOX), showed increased expression in affected tissues.

More Related Videos

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

Related Experiment Videos

Last Updated: Jun 28, 2026

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
06:14

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

Area of Science:

  • Periodontology
  • Biomaterials Science
  • Connective Tissue Biology

Background:

  • Occlusal forces are crucial for maintaining periodontal tissue health.
  • Understanding the impact of reduced occlusal function on gingival tissues is essential for regenerative therapies.

Purpose of the Study:

  • To investigate the effects of occlusal hypofunction on gingival tissue integrity.
  • To analyze alterations in gingival extracellular matrix biosynthesis, specifically collagen production, under hypofunctional conditions.

Main Methods:

  • Wistar rats underwent maxillary molar extraction to induce occlusal hypofunction.
  • Gingival tissues were analyzed histologically (H&E staining) and via immunohistochemistry for connective tissue growth factor (CTGF) and lysyl oxidase (LOX) expression at 2 and 4 weeks post-surgery.

Main Results:

  • Occlusal hypofunction led to collagen fiber disorientation and fibroblast proliferation in gingival tissue.
  • Enlarged epithelial intercellular gaps were observed in the hypofunctional group.
  • Significantly increased expression of CTGF and LOX was detected in gingival tissues experiencing occlusal hypofunction (P < .05).

Conclusions:

  • Occlusal hypofunction negatively impacts the structural integrity of gingival tissue.
  • Reduced occlusal forces alter the biosynthesis of the gingival extracellular matrix, evidenced by changes in CTGF and LOX expression.