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Osteoprotegerin in gingival crevicular fluid under long-term continuous orthodontic force application
Hilal Uslu Toygar1, Beyza Hancioglu Kircelli, Sule Bulut
1Department of Periodontology, Faculty of Dentistry, Baskent University, Ankara, Turkey. hilaluslu@hotmail.com
Objective:
To investigate the level of osteoprotegerin (OPG) in gingival crevicular fluid (GCF) during tooth movement.
Materials And Methods:
Twelve patients (13-17 years of age) requiring canine distalization participated in the study. GCF sampling was done at baseline, 1 hour, 24 hours, 168 hours, 1 month, and 3 months from the distal sites of the test and with control teeth after the application of mechanical stress. OPG concentration was detected by enzyme-linked immunosorbent assay.
Results:
OPG concentrations in distal sites of the test teeth were decreased in a time-dependent manner. Decreasing is significant when compared with the baseline measurements (P = .038). Variability was detected in the levels of OPG concentration in the distal sites of the control tooth throughout the experimental period.
Conclusion:
OPG is one of the key mediators responsible for alveolar bone remodeling during tooth movement.