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Related Concept Videos

Glial Cells01:04

Glial Cells

Overview

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Related Experiment Video

Updated: Jun 28, 2026

Derivation of Glial Restricted Precursors from E13 mice
08:56

Derivation of Glial Restricted Precursors from E13 mice

Published on: June 20, 2012

Expression profiling of human glial precursors.

James T Campanelli1, Robert W Sandrock, Will Wheatley

  • 1Q Therapeutics, Inc. 615 Arapeen Dr., Ste. 102, Salt Lake City, UT 84108, USA. jcampanelli@qthera.com

BMC Developmental Biology
|October 25, 2008
PubMed
Summary

Researchers profiled gene expression in human glial precursors, identifying unique genes and pathways crucial for their development. This data aids in purifying these cells and understanding their differentiation.

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Last Updated: Jun 28, 2026

Derivation of Glial Restricted Precursors from E13 mice
08:56

Derivation of Glial Restricted Precursors from E13 mice

Published on: June 20, 2012

Progenitor-derived Oligodendrocyte Culture System from Human Fetal Brain
14:26

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Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions
08:00

Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions

Published on: June 4, 2020

Area of Science:

  • Neuroscience
  • Genomics
  • Developmental Biology

Background:

  • Gene expression databases were created for human glial precursors, neuronal precursors, astrocyte precursors, and neural stem cells.
  • The study focused on comparing the gene expression profile of glial precursors with other neural cell populations.

Purpose of the Study:

  • To generate a comprehensive gene expression profile for human glial precursors.
  • To identify unique genes and signaling pathways involved in glial precursor proliferation and differentiation.

Main Methods:

  • Analysis of 14 distinct cell population samples.
  • Immunocytochemical analysis to distinguish cell populations based on surface markers.
  • Gene expression profiling and validation using RT-PCR.

Main Results:

  • Identified 458 uniquely expressed genes in the human glial precursor cell population.
  • Confirmed expression of key differentiation pathway genes within each cell population.
  • Reported genes encoding cell surface markers potentially useful for glial precursor identification and purification.

Conclusions:

  • Provided a detailed gene expression profile for human glial precursors.
  • Suggested key signaling pathways regulating human glial precursor proliferation and differentiation.
  • Highlighted the utility of the data for improving glial precursor purification and media formulation.