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Related Concept Videos

Sex Linked Disorders01:43

Sex Linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Sex-linked Disorders01:43

Sex-linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
The Ratio of X Chromosome to Autosomes02:45

The Ratio of X Chromosome to Autosomes

In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.  
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
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Urinary Tract Calculi VI: Surgical Management01:25

Urinary Tract Calculi VI: Surgical Management

Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...

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Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
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Consensus statement on management of intersex disorders.

I A Hughes1, C Houk, S F Ahmed

  • 1Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK. iah1000@cam.ac.uk

Journal of Pediatric Urology
|October 25, 2008
PubMed
Summary

This review synthesizes expert consensus on managing intersex disorders, focusing on diagnosis, psychosocial aspects, and long-term outcomes. It proposes future research directions for improved patient care and advocacy.

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Area of Science:

  • Pediatric Endocrinology
  • Genetics
  • Child Psychology

Background:

  • Intersex variations require multidisciplinary, long-term management involving families and various specialists.
  • Significant advancements have been made in diagnosis, surgical interventions, and understanding psychosocial challenges.
  • Patient advocacy is increasingly recognized and integrated into care strategies.

Purpose of the Study:

  • To comprehensively review the management of intersex disorders from a broad perspective.
  • To evaluate available data on longer-term outcomes for individuals with intersex variations.
  • To formulate recommendations and proposals for future research in the field.

Main Methods:

  • Convened working groups comprising 50 international experts in pediatric endocrinology and related fields.
  • Conducted an evidence-based literature review to inform a defined set of questions for the working groups.
  • Facilitated a consensus-building meeting to agree on a framework for the final document.

Main Results:

  • The paper presents a consensus document developed through a rigorous review and expert deliberation process.
  • It addresses current best practices and identifies gaps in knowledge regarding intersex disorder management.
  • The findings highlight the importance of a holistic approach encompassing medical, psychological, and social aspects.

Conclusions:

  • The established framework provides a foundation for standardized and improved management of intersex disorders.
  • Further research is crucial to enhance long-term outcomes and patient well-being.
  • Collaboration between professional societies like LWPES and ESPE is vital for advancing the field.